Progestin-Primed Ovarian Stimulation Versus GnRH Analogue as regard (Pregnancy Loss and Neonatal Birthweights): A Retrospective Analytical Study.

Document Type : Original Article


1 Department of Obstetrics and Gynecology, faculty of medicine, Minia University, Minia, Egypt

2 Department of obstetric and gynecology, Faculty of Medicine, Minia University, Minia, Egypt


Background; Controlling premature ovulation is a major assisted reproductive technology problem. During 40 years of usage, gonadotropin releasing hormone (GnRH) analogues (agonist and antagonist) have been shown to reduce pituitary activity and prevent LH surges.

Aims and objectives: to compare the outcome of vitrified embryos originating from Progestin Primed Ovarian Stimulation vs. that originating from GnRH analogue protocols especially as regard : Pregnancy outcome and neonatal birth weights.

Methods: This retrospective study took place at IVF center, all case files during period from January to December, 2022. Case files divided into 2 study groups A and B , Group A: Vitrified embryos originated from PPOS protocol and Group B: Vitrified embryos originated from conventional protocols using GnRH analogue group.

Result: pregnancy loss rates were found to be 18.2% in the GnRH Analogue group and 20.4% in the PPOS group, with an odds ratio (OR) of 1.155 and a 95% confidence interval (CI) of 0.551-2.422. The p-value of 0.702 with no statistically significant disparity in pregnancy loss rates between the two groups.the percentages of low birthweight (2500 g) and high birthweight (4000 g) infants were comparable between the GnRH Analogue and PPOS groups with odds ratios close to 1

Conclusion: The occurrence of pregnancy loss during the whole gestation period and the birthweights of neonates in FET cycles employing embryos from PPOS were similar to those from GnRH analogue regimens.

Additional inquiries should prioritize the examination of the prolonged safety of offspring resulting from the PPOS technique.


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